Irresti: Fokale Kortikale Dysplasie Operation

Fokale Kortikale Dysplasie Operation

Focal cortical dysplasia fcd is a congenital abnormality of brain development where the neurons in an area of the brain failed to migrate in the proper formation in utero. Focal cortical dysplasia fcd frequently is associated with medically intractable epilepsy.

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Focal cortical dysplasia also is potentially a surgically remediable syndrome for patients with associated intractable seizures although reported outcomes concerning postoperative seizure control have been mixed.

Fokale kortikale dysplasie operation. Focal cortical dysplasia fcd covers a spectrum of conditions in which the neuropathologic and electroclinic presentations and the surgical outcomes vary. We reviewed the mr data of 49 patients treated surgically for intractable. Despite increasing awareness surgery historically yields less promising results than other well recognized.

There are both genetic and acquired factors that are involved in the development of cortical dysplasia. The aim of this study was to identify the mr features of histologic subtypes of fcd that would be useful for differential diagnosis. Focal means that it is limited to a focal zone in any lobe.

13 the advent of powerful neuroimaging technology has revolutionized the identification and management of this difficult group of disorders. Both genetic and acquired factors are involved in the pathogenesis of cortical dysplasia. Focal cortical dysplasia fcd is a malformation of cortical development which is the most common cause of medically refractory epilepsy in the pediatric population and the secondthird most common etiology of medically intractable seizures in adults.

Focal cortical dysplasia is a congenital abnormality where there is abnormal organization of the layers of the brain and bizarre appearing neurons. Focal cortical dysplasia fcd was first described in human beings in 1971 taylor and others 1971 when microscopic abnormalities including large bizarre neurons and cortical disorganisation were reported in excised areas of epileptic foci in 10 patients with drug resistant epilepsyfcd usually occurs in childhood but can occur at any age gaitanis and donahue 2013. Focal cortical dysplasias fcd represent a heterogeneous group of disorders of cortical formation which may demonstrate both architectural and proliferative features.

Epilepsy surgery for focal cortical dysplasia at ucla. In general three types of cortical dysplasia are recognized. Surgery for drug resistant epilepsy dre with focal cortical dysplasia fcd often requires multiple non invasive as well as invasive pre surgical evaluations and innovative surgical strategies.

Focal cortical dysplasia is a malformation of cortical development which is the most common cause of medically refractory epilepsy in the pediatric population and the secondthird most common etiology of medically intractable seizures in adults. They are one of the most common causes of epilepsy and can be associated with hippocampal sclerosis and cortical glioneuronal neoplasms.

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